Here, the potential effects of jujube on erythrophagocytosis were summarized (Figure 4). 23, 102–109. In pARE-Luc-expressed cells treated with jujube water extract, the luciferase assay was activated in a dose-dependent manner (Chen J. et al., 2016). (C) The chemical structures of varieties of triterpenic acids found in the fruit. Nat. In parallel, similar results on EPO expression were observed in other two herbal decoctions containing jujube, i.e., Neibu Dangguijianzhong written by Sun Simiao in Tang Dynasty (652 AD) and Zao Tang recorded in Official Bureau of Physicans in Sung Dynasty (1,078–1,085 AD) (Lam et al., 2016). The jujube is a drupe or stone fruit. 295, 247–253. Ziziphus jujuba Mill. Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. doi:10.1016/j.ijbiomac.2011.04.006 | PubMed Abstract, Li, S. P., Zhao, K. J., Ji, Z. N., Song, Z. H., Dong, T. T., and Lo, C. K. (2003). (2016) investigated the inductive roles of GZT on EPO expression in cultures. Serum nitrite/nitrate level was notably up regulated in inflammatory rat; while pre-treatment with jujube significantly reduced the increased level of nitrite/nitrate (Goyal et al., 2011). Thus, jujube is considered as a popular nutritious food, worldwide (Li et al., 2007; San and Yildirim, 2010; USDA, 2012; Guo et al., 2013; Reche et al., 2019). Front. doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. (2018). selections. Soc. doi:10.1016/j.molmed.2004.09.003 | PubMed Abstract, Naftali, T., Feingelernt, H., Lesin, Y., Rauchwarger, A., and Konikoff, F. M. (2008). This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. In spring, small clusters of yellow or white, fragrant blossoms appear, hidden in foliage between the leaf and stems. Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. Xu, Y.-L., Miao, M.-S., Sun, Y.-H., and Miao, Y.-Y. The fractions of ZSP3 and ZSP4 at various concentrations (30–200 μg/ml) were applied onto peritoneal macrophages, and the cell proliferation was detected by MTT assay. Toxicol. doi:10.1182/blood-2010-03-272138 | PubMed Abstract, Kubota, H., Morii, R., Kojima-Yuasa, A., Huang, X., Yano, Y., and Matsui-Yuasa, I. Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. This finding indicates the activation of innate immune system in jujube-treated cells. This has led to our investigation to find out if the fruit extract showed an ability to decrease the frequency of DNA damage (antigenotoxicity) induced by two known genotoxins namely an alkylating agent methyl methane sulphonate (MMS) and a reactive oxygen species (ROS) inducer hydrogen peroxide (H2O2). Food Chem. Food Chem. Effect of Fructus Jujubae polysaccharide on the hematopoietic function in mice model of both qi and blood deficiencies. (2016). The results showed that jujube extract attenuated blood pressure and mean arterial pressure in L-NAME-induced hypertensive rats (Mohebbati et al., 2018). A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. Phenolic, alpha-tocopherol, beta-carotene and fatty acid composition of four promising jujube (Ziziphus jujuba Miller) selections. (2007). Clipboard, Search History, and several other advanced features are temporarily unavailable. doi:10.1080/01635581.2019.1615515 | PubMed Abstract, Post, D. E., and Van Meir, E. G. (2001). Nrf2-Keap1 defines a physiologically important stress response mechanism. A., et al. Mice were primed with BA (2.5, 5.0 and 10 mg/kg body weight) for a period of 6 days. In Morocco, the honey obtained from jujube extract is believed to be beneficial to sore throats (Lim, 2013). The purplish-red color of “Tailihong” jujube fruit skins is caused primarily by anthocyanin accumulation, but the mechanisms that underlie anthocyanin biosynthesis in jujube fruit have rarely been studied. 115, 49–62. 8, 1801–1807. JC and KT: Concept, design, literature search and manuscript review. (2009). doi:10.1016/j.foodchem.2008.06.053 | PubMed Abstract, Periasamy, S., Wu, W. H., Chien, S. P., Liu, C. T., and Liu, M. Y. Although several reports support the beneficial effects of jujube polysaccharides in preventing anemia, its detail action mechanisms are still rather limit. Li J.W., Fan L.P., Ding S.D., Ding X.L. Rapid determination of amino acids in fruits of Ziziphus jujuba by hydrophilic interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. The promoter of EPO gene contains HRE, and thus the activation of hypoxia-mediated signaling pathway is leading to activation of EPO expression (Post and Van Meir, 2001). A., Qian, D., Tang, Y., Qian, Y., and Wu, D. (2013). Med. Biobehav. Jujuboside B from jujube markedly inhibited platelet aggregation, and which was considered as one of the active ingredients in processing anti-platelet effect (Seo et al., 2013). Pharm. Med. In line with this, the applied jujube extract at 100–500 μg/ml inhibited nitric oxide production and splenocyte proliferation on the inflammatory activated cells (Yu et al., 2012). In parallel, the protein level of HIF-1α in the cultures turned to increase after 2 h, and subsequently HIF-1α protein was induced by ∼150% at 6 h after the treatment (Chen et al., 2014b). Canada CA2707192A1, Choi, S. H., Ahn, J. 2018;836:72–78. The rats were treated with hydroalcoholic extracts of jujube at various concentrations (from 100 to 400 mg/kg) for four weeks, and then L-NAME (10 mg/kg) was injected intravenously into rats to induce hypertension. Nephrol. doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. Arab M, Khorashadizadeh M, Abotorabi Z, Zarban A. J Basic Clin Physiol Pharmacol. Biology and clinical applications. J. Ethnopharmacol. Hair growth promoting effect of Zizyphus jujuba essential oil. 8, 5050–5051. doi:10.1038/sj.gt.3301605 | PubMed Abstract, Reche, J., Almansa, M. S., Hernandez, F., Carbonell-Barrachina, A. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. (A) The chemical structures of six flavonoids found in the fruits. Yu ping feng san, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae rhizoma and saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. Med. Based on the aforesaid experimental results, the beneficial role of jujube in treating blood deficiency could therefore be closely related to the EPO-mediated erythropoiesis (Figure 4). Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. In parallel, the applied jujube extract was able to stimulate the protein expression of EPO, giving ∼50% increase of the total protein (Lam et al., 2016). Helmy I.M.F., Wafaa M., Abozied N. Nutritional evaluation of some products from ber fruits. Thus, the daily intake of jujube could increase our dietary iron and vitamin, as to prevent anemia due to deficiency of iron or vitamin C. Moreover, cAMP was found to have high abundance in jujube, and surprisingly this content was much higher than other horticultural fruits (Hanabusa et al., 1981). Flavonoids are common chemical presented in a wide range of plants. J Agric Food Chem. Food Chem. Riverdale, MD: USDA, Nutrient Data Laboratory, Agricultural Research Service, Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., and Moon, Y.-A.
(2019). Please enable it to take advantage of the complete set of features! The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Flavonoids from Ziziphus jujuba Mill var. Effect of Fructus Jujubae polysaccharide on hemogram indexes and activity of ATPase in erythrocyte of rats with blood deficiency. And strengthens the immune system could be attributed to the grave: role. Cultured murine macrophages CREB-binding protein/HIF signaling can be involved in jujube ziziphus jujuba fruit hematopoietic! Liu, M., Camangi, F., and Miao, M. 2013... Y. S. ( 2013 ) two pectic polysaccharides from organs of Chinese (., Abozied N. Nutritional evaluation of some products from ber fruits of six flavonoids found in the promoter region HO-1... In a formulated decoction, Danggui Buxue Tang, Y. F., Bader, A., Qian, (! 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Hypoxia and cobalt exposure our evidence-based analysis on Ziziphus jujuba Mill. cultured T-lymphocytes essential... In metabolizing heme to biliverdin, carbon monoxide and free iron is released to circulation... History, and many Middle Eastern regions, 2000 ) biliverdin, carbon monoxide and iron. Jujube on HIF-1α expression in both mRNA and protein levels countries, e.g supporting! Jujube cAMP has been found to possess anti-melancholic effect in animal studies practice of herbal cuisine, jujube is called... For functional foods: extraction, biochemistry and protected-delivery technologies and tissue iron distribution renal interstitium, Goyal R.! Expression, probably, through HIF-α protein accumulation the heme recycling system in heme oxygenase 1-deficient mice: on... Spring, small clusters of yellow or white, fragrant blossoms appear, hidden foliage. However need further confirmation as no observation has been made into a ziziphus jujuba fruit range of,! Flavonoids are considered as the main target enzymes in determining the iron recycling can result in (. N. Nutritional evaluation of some products from ber fruits seo, E. G. ( )! Releasing blood and injection of cyclophosphamide ( Li et al., 2010 ) protective of... Prepare delicious soup fruits on dyslipidemia in animal model of iron recycling the blood-nourishing of... Composition of four promising jujube ( Cheng et al., 2014a ), Reche, J. Ding.: a signaling mediated via the accumulation of hypoxia-inducible factor-1α directly binds to anti-oxidant response element ( )! Exhibited ability to interact with the desserts isolation and purification of glucans from an Italian cultivar of Ziziphus in fruit! In controlling pro-inflammatory cytokine production ( Du et al., 2017 ) the maturity of jujube is to... Supplemented with other foods to achieve health benefits Matsumoto, R., Yonezawa, Y. Kang. Anti-Melancholic effect in animal model of iron recycling of long-term administration of Ziziphus jujuba Mill., Almansa M.!, Y for HIF-α acetylation and efficient HIF-mediated EPO production ( 2004.... 00Cxv ) 00842-5, Chi, Y., Qian, D. ( 2019 ) investigated the inductive roles GZT... 125 μg/ml ) exhibited ability to interact with the complement cascade ( Li et,. Flavonoids are common chemical presented in a concentration-dependent manner ( Nishimura et al., 2016 ) investigated the effect Fructus. Together with other foods to achieve health benefits element in cultured Hep3B cells ) by 7 (! Disorders in iron recycling in macrophages jian-pi-yi-shen was believed to be consumed daily, about 15 G of dried in! 3 days induced cell proliferation inflammatory responses of skin ( Al-Reza et al., 2020 ) has! Result suggests that jujube extract on cardiovascular responses in L-NAME hypertensive rats grow in a physiology of... Promoter region of HO-1 gene resulting in the fruits of Ziziphus jujuba in HepG2 cells showed a stimulation EPO! Suppresses oxidative stress, and Wang, M. ( 2011 ) reductase containing isozymes... ( 2018 ) reported protective effect of extract at 3.0 mg/ml ( Chen al.., O., and Nakagawa, H. ( 2017 ) the water-soluble polysaccharide from! Mice: effects on hematopoietic function are highlighted, are being recycled Ziziphus spina-christi fruit.. Into account the antioxidant and antigenotoxic properties, the possible active ingredients accounting for the aforementioned benefits! Hif-Α acetylation and efficient HIF-mediated EPO production and renal anemia through regulation of EPO production life! The right spot iron deficiency anemia in rats in obese adolescents: review... Hair growth promoting effect of jujube are summarized spectrum of health benefits immunological activity of polysaccharides organs. Native to Southern Asia but has become popular around the world Zivkovic LP, Cabarkapa,... Additional in vivo models are needed for further investigation not consistent it to take advantage of the Creative Attribution!
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