That includes cyclins, transcription factor E2F, and many other enzymes. There are several published studies that evaluate whether lycopene in tomato products or supplements could have protective effects against prostate cancer and cardiovascular disease. Lycopene health benefits have been shown to include the prevention of a wide variety of cancers, including prostate, lung, colon, cervical and breast cancer. How does Lycopene affect prostate cancer? Lycopene’s main health benefit is its antioxidant function. At present, meta-analysis of clinical studies of lycopene for prevention of prostate cancer in men does not yet support the definitive clinical use of this carotenoid in a preventive setting. Similarly, a recent review of clinical trials has recently shown how common it is to have natural products and foods as a source of cancer-fighting molecules (2). Holzapfel, N., Holzapfel, B., Champ, S., Feldthusen, J., Clements, J., & Hutmacher, D. (2013). Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Hunziker W, Goralczyk R, Wertz K. FASEB J. The Journal of nutrition, 135(8), 2060S-2061S. These include watermelon, guava, apricot, pink grapefruit, and rosehips. Arch Biochem Biophys. J Mol Histol. Further studies have demonstrated higher fruit and vegetable intake, which in turn increases lycopene intake, helps lower prostate cancer risk [Source: Smith-Warner]. These cells display an exaggerated replication that creates a tumor. Cell cycle arrest: Cell proliferation requires preparation by the dividing cell. Arathi, B. P., Sowmya, P. R. R., Kuriakose, G. C., Vijay, K., Baskaran, V., Jayabaskaran, C., & Lakshminarayana, R. (2016). Also, try other colored fruits like papaya, and don’t think tomato products are deprived of lycopene. Thus, a good supplement for your prostate does not only fight prostate cancer but also slows down the growth of this vital gland. We all know that vitamin A is fundamental for an excellent vision, but not all of us know it is also an outstanding antioxidant. In pilot studies with cancer patients, daily ingestion of lycop… Androgen signaling, cytokine (IL-6, IL-4) and growth factor signaling (e.g., IGF, Wnt/beta-catenin) cross-talk via PI3K/Akt, MAPK, and Jak/STAT pathways have been identified as major controllers of prostate growth. However, there is not enough evidence to say that lycopene provides such health benefits. All of these changes block the groundwork that is required for cell division and freezes cancer cells into a phase of the cell cycle (9). 133 (7), p2336-41. The next reason to get lycopene from your diet instead of supplements is that supplements will contain much smaller doses than what you can get from just a small amount of food. However, there are various sources to choose from. Similar to Pygeum, Lycopene too inhibits androgen receptors inside the prostate. 2019 May;31(3):222-229. doi: 10.1097/CCO.0000000000000519. Unlu, NZ; et al., lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. 75 (1), p54-60. A recent study showed that 10 servings of tomato every week is associated with a reduced risk of prostate cancer by 20% in the United Kingdom. Nutrients. Read about the history of research, laboratory, and human studies on various prostate supplements, such as calcium, green tea, lycopene, pomegranate, selenium, soy, and vitamin E in this expert-reviewed summary. Obermüller-Jevic, U. C., Olano-Martin, E., Corbacho, A. M., Eiserich, J. P., Van der Vliet, A., Valacchi, G., … & Packer, L. (2003). Published 2014 Jan 27. doi:10.3390/nu602046. However, more high-quality studies are needed in this area. It is associated with impressive benefits for patients with prostate cancer.  |  (BPH), a condition said to affect more than half of all men over. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. These benefits were exerted from lycopene from whole foods rather than as an extract. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 12(1), 49-75. Evidence-based complementary and alternative medicine, 2013. Regulation of growth factors: There are chemicals in the body that serve as signals or red flags that promote cellular growth and proliferation. If you don’t tolerate tomatoes, consider getting a supplement with at least 10 mg of lycopene per capsule. Endogenous production of reactive oxygen species during inflammation may lead to oxidative DNA damage, which can be mutagenic, if unrepaired. Cell Prolif. 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