Bienvenue sur le site web de l'ECHA. At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. Calcium Carbonate, Calcium Chloride, Calcium Gluconate, Calcium Phosphate . The circumstances leading to the incident included the method of application of the fertiliser, low rainfall and the absence of subsequent irrigation of the fertilised pastures. Exposure to 0.212mg/L calcium carbonate (nano) resulted in very limited alterations in BAL parameters only. Calcium salts (calcium carbonate, calcium chloride, and calcium magnesium acetate): Calcium salts are the most hazardous as they are the most severe irritants of all the ingredients in ice melts. Diagnosis is primarily clinical, but for some poisonings, blood and urine tests can help. If symptoms persist call a doctor. In the body it is converted to calcium carbonate and cyanide, the latter inhibiting certain catalytic and oxidation-reduction processes, especially the cysteine-glutathione system. Unlike calcium hydroxide, it absorbs very little CO 2 in aqueous solutions and is therefore insensitive to atmospheric fluctuations. Not listed EC No. Repeat dose toxicity - inhalation: A 90 day inhalation toxicity study in the rat is has been performed using uncoated nano calcium carbonate in which no systemic toxicity was observed. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 01/16/2012 Revision date: 03/05/2015 Supersedes: 01/16/2012 Version: 2.0 04/13/2015 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Calcium supplements usually come in tablet or flavored soft-chew formulations and are readily found in many households. A healthy diet generally requires 1,000 mg of calcium per day. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. This property is used in calibrating pH equipment. ALP, GGT, LDH, total protein) in bronchoalveolar lavage (BAL) fluid of animals of the mid, high and top concentration main groups; II) slight changes in differential white blood cell numbers in BAL fluid of animals of the high and top concentration main groups, characterized by an increase in the number of neutrophils and – for females of the top concentration group only – a slight increase in the number of lymphocytes; and III) an increased lung weight in males and females of the top concentration main group. The exposure conditions were close to their respective targets. Paper fabrication; Plastic fabrication; Ceramics; Toxicology. study was to provide data on the sub-chronic (13‑week) toxicity of inhaled c, main groups of 10 male and 10 female rats each were exposed by nose-only inhalation exposure to 0 (control), 0.026 (± 0.002), 0.123 (± 0.006), 0.212 (± 0.013) or 0.399 (± 0.019) mg/L c. for 6 hours/day, 5 days/week over a 13-week period (65 exposure days). But, long-term overuse is more serious than a single overdose, because it can cause kidney stones and more serious damage to kidney function. Calcium Carbonate Toxicology Identification and Uses. Precipitated Calcium Carbonate Safety Data Sheet according to Federal Register / Vol. DO NOT use it to treat or manage an actual poison exposure. Repeat dose toxicity - inhalation: A 90 day inhalation toxicity study in the rat is has been performed using uncoated nano calcium carbonate in which no systemic toxicity was observed. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). Calcium carbonate is also a food additive approved by the Council Directive 95/2/EC on food additives (the substance has the acronym E 170). Therefore, the. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data. . These changes were largely, but not fully, reversible within a 4‑week recovery period after the last exposure. Several potential adverse effects have been reported following calcium supplementation e.g. The exposure to the test material was well tolerated by the animals. Eye Contact: No information found, but presumed to cause mechanical irritation. effects on kidney function, milk-alkali syndrome, kidney stones and interactions with minerals. 453/2010 01/05/2015 EN (English) 2/5 SECTION 4: First aid measures 4.1. Le carbonate de calcium pur est employé seulement dans des applications où la présence d'impuretés comme la silice ... Aucun effet nuisible n'a été rapporté suite à l'inhalation de poussières de carbonate de calcium pur autre que des effets mineurs et réversibles, tels que toux et phlegme, dus à des milieux très empoussiérés. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Justification for classification or non-classification, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. Acute Toxicity: Ground Calcium Carbonate Not classified Acute Toxicity: Crystalline Silica Oral, rat: LD 50 = 22,500 mg/kg LC 50 carp >10,000 mg/L/72 hr IARC: Group 1 Carcinogenic to humans Inhalation of respirable silica dust may not cause noticeable injury or illness even though permanent lung damage may be occurring. Calcium Carbonate ignites on contact with FLUORINE. While it is not possible to measure or accurately predict an octanol/water partition coefficient for inorganic ionic substances, such a value would be expected to be very low. Calcium Carbonate Safety Data Sheet according to Federal Register / Vol. Product identifier Substance name: Calcium carbonate (natural) Synonyms: limestone, chalk, calcite, … Serious Eye Damage/Irritation Not expected to cause eye irritation except as a “foreign body”. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 09/11/2012 Revision date: 05/18/2015 Supersedes: 09/11/2012 Version: 2.0 05/18/2015 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Clinical signs, behavioural assessments, bodyweight change, food and water consumption were monitored during the study. If you or someone you are with has an exposure, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) … - Confusion, bizarre or aggressive behavior. 1 Material Safety Data Sheets Calcium Carbonate • Looe in te Lab • Loose in the Lab, Inc. Issue Date 6/11/2015 9462 South 560 West ... of inhalation. Repeatas needed every 5–10 minutes. 77, No. Dehydration, other medications, and other conditions including kidney problems, can … 1981 Jan;27(1):98-102. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. A 28 day study in the mouse is also available, as well as a number of human studies on bulk calcium carbonate. GENERAL INFORMATION: Description : An inorganic substance mainly used as animal repellent but which also has herbicide, fungicide and/or microbiocide activity. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 04/10/2014 Revision date: 12/29/2016 Supersedes: 07/08/2016 Version: 1.2 12/29/2016 EN (English US) Page 1 SECTION 1: Identification . Repeat dose toxicity - oral: A 14 day range finder study, a 28 day and a 90-day repeat dose oral toxicity study in rats are available that have evaluated the repeated dose toxicity of uncoated nano calcium carbonate. Eyes: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Calcium carbonate occurs in the natural environment and humans are widely exposed to naturally occurring calcium carbonate, e.g. 1.1. This site is not fully supported in Internet Explorer 7 (and earlier versions). Under the conditions of the current study, inhalation exposure to 0.399 mg/L calcium carbonate (nano) resulted in treatment-related changes in the lower airways, characterized by an increased lung weight accompanied by slight increases in BAL‑derived inflammation and cytotoxicity biomarkers. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). 3. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. All carbonate salts are on the FDA generally regarded as safe list. The aerodynamic particle size distribution of the test atmospheres was highly comparable across the groups with an average mass median aerodynamic diameter (MMAD) in the range of 1.29 – 1.35 µm and a geometric standard deviation (gsd) of 1.52 – 1.54. Routes of exposure Inhalation. Ingested calcium and carbonate ions are actively regulated by the body. No indications for systemic toxicity of inhaled calcium carbonate (nano) were observed in this study. Calcium Carbonate CS95 Granulation Safety Data Sheet according to Regulation (E C) No. A transient decrease in growth (females) or food consumption (males), observed in the top concentration group shortly after the initiation of exposure, was no longer observed after a few weeks. Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. Local effects were observed in the lung, these were irritation and increased lung weights. The European Commission Scientific Committee on Food has produced a report on the Tolerable Upper Intake Level of Calcium (2003). I-Acute Exposure A-Inhalation All animals were subjected to a gross necropsy examination and histopathological evaluation of selected tissues was performed. I-Acute Exposure A-Inhalation The NOAEL was therefore reported to be 1300 mg/kg bw/day. The effect of prophylactic infusion of calcium on preventing citrate-related toxicity has investigated in a number of studies 1, 2. Calcium Carbonate CM90 Granulation Safety Data Sheet according to Regulation (E C) No. Immediately call a doctor. Their dietary calcium intakes are often not known. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. No indications for systemic toxicity of inhaled c, Exposure to the test material resulted in local changes in the lower airways. First-aid measures after inhalation : Move to fresh air in case of accidental inhalation. Hence the NOAEC for local effects was established as 0.212 mg/L and the LOAEC at 0.399 mg/L. Calcium hypochlorite is not flammable, … Given the physico-chemical properties of calcium carbonate, it is not expected that the substance would penetrate the skin in any significant quantity and so would therefore not cause any toxic effects following repeated dermal exposure. Chronic toxicity. At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. Effects are only seen when this dose is significantly exceeded. Calcium sulfate dihydrate 13397-24-5 0-5 Calcium carbonate 1317-65-3 0-2 Calcium oxide 1305-78-8 0-2 Magnesium oxide 1309-48-4 0-2 Silica, Crystalline (Quartz)/Sand 14808-60-7 60-100 Section 4. When dogs ingest these supplements in large amounts, vomiting and diarrhea or constipation are common, with potential for transiently elevated calcium blood levels. Potential Adverse human health effects and symptoms : Practically non-toxic if swallowed (LD50 oral, rat > 2000 mg/kg). Haematology results, clinical chemistry analysis and necropsy findings did not show any treatment-related changes. This article is for information only. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues)[1]. The aerodynamic particle size distribution of the test atmospheres was highly comparable across the groups with an average mass median aerodynamic diameter (MMAD) in the range of 1.29 – 1.35 µm and a geometric standard deviation (gsd) of 1.52 – 1.54. Give10% calcium gluconate, 10–20 mL (children, 0.2–0.3 mL/kg), or 10%calcium chloride, 5–10 mL (children, 0.1–0.2 mL/kg), slowly IV. Skin Contact: Not expected to be a health hazard from skin exposure. Ingestion Calcium carbonate is practically non-toxic by ingestion. EC number: 207-439-9 | CAS number: 471-34-1. This product is absorbed by the respiratory tract. - Inhalation may cause burning sensation in nasopharynx and chest, coughing, and/or dizziness. Identification . It generally has a low ecotoxicity. One of the most prevalent minerals within the human body, calcium is largely retained by the … The exposure to the test material was well tolerated by the animals. Ammonium Bicarbonate, Ammonium Carbonate, Calcium Carbonate, and Potassium Carbonate that are accessible at the European Chemicals Agency’s (ECHA) website. BAL measurements are usually a rather sensitive toxicological read-out parameter, and it is not uncommon to observe treatment-related changes at concentrations below a level at which histopathology is induced. Animals of the main groups were sacrificed on the day after the last exposure. Therefore, a classification as STOT RE is not justified and no classification is proposed. First-aid measures Inhalation IF INHALED: Remove person to fresh air and keep comfortable for breathing. 2). No systemic toxicity was observed in a 90-day inhalation study where rats were exposed to uncoated calcium carbonate at a maximum concentration of 0.399 mg/L, stated as the NOEC. Inhalation: Excessive concentrations of a nuisance dust may cause nuisance condition such as coughing, sneezing, and nasal irritation. Acute calcium poisoning is rare, and difficult to achieve unless calcium compounds are administered intravenously. The aim of the present study was to provide data on the sub-chronic (13‑week) toxicity of inhaled calcium carbonate (nano) in rats. 1.1. Calcium carbonate overdose occurs when someone takes more than the normal or recommended amount of a product containing this substance. Thus, the NOAEL for uncoated nano calcium carbonate in this study was >1000 mg/kg bw/day. Symptoms vary, but certain common syndromes may suggest particular classes of poisons. The exposure to the test material was well tolerated by the animals. Scanning electron microscopy of aerosol samples confirmed that the particles were primarily present in agglomerates, which varied in size (ranging 60 nm – 30 µm, with trace amounts of primary particles) and shape, with little to no difference between the groups. The occurrence of a suspected mixed ammonia and nitrate fertiliser poisoning that led to acute illness and fatalities in cattle is described. Based on these observations, the NOAEC for local effects of sub-chronic inhalation exposure to uncoated nano calcium carbonate was placed at 0.212 mg/L. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues)[1]. It is one of the constituents of hydroxyapatite and is the main constituent of the bones and teeth. The use of calcium carbonate supplements in doses up to 2000 mg/day, and thereby achieving total daily calcium intakes up to more than 3000 mg/day, for preventive purposes in presumably healthy subjects, has not provoked the development of the milk-alkali syndrome, whereas the administration of large amounts (11.2 g calcium/day) of calcium carbonate in addition to large amounts of milk (1.8 g calcium/day) over 7 days to 20 gastric/duodenal ulcer patients resulted in reversible hypercalcaemia (2.8 mmol/L) in nine patients and renal insufficiency in all. Special Remarks on Toxicity to Animals: Not available. Define avian calcium poisoning. 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